منابع مشابه
HIV Drug-resistant Strains as Epidemiologic Sentinels
Observed declines in drug resistance to nucleoside reverse transcriptase inhibitors among persons recently infected with HIV-1 in monitored subpopulations can be interpreted as a positive sign and lead public health officials to decrease efforts towards HIV prevention. By means of a mathematical model, we identified 3 processes that can account for the observed decline: increase in high-risk be...
متن کاملDrug-resistant HIV infection among drug-naive patients in Israel.
BACKGROUND In Israel, <0.06% of the general population is infected with human immunodeficiency virus (HIV), with a much higher prevalence among specific groups. These groups are distinguished demographically by risk behavior category and by virus subtype. We investigated transmission of drug resistance within groups to assess the impact of these factors. METHODS Plasma samples from >15% of al...
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Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learnin...
متن کاملGlobal threat from drug resistant HIV in sub-Saharan Africa.
Roll-out of antiretroviral treatment for HIV in sub-Saharan Africa has been accompanied by rising rates of drug resistance. Raph Hamers and colleagues call for improved patient management and population based drug resistance surveillance to be integrated into national treatment programmes.
متن کاملAptamers that recognize drug-resistant HIV-1 reverse transcriptase
Drug-resistant variants of HIV-1 reverse transcriptase (RT) are also known to be resistant to anti-RT RNA aptamers. In order to be able to develop diagnostics and therapies that can focus on otherwise drug-resistant viruses, we have isolated two aptamers against a well-known, drug-resistant HIV-1 RT, Mutant 3 (M3) from the multidrug-resistant HIV-1 RT panel. One aptamer, M302, bound M3 but show...
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ژورنال
عنوان ژورنال: BMJ
سال: 2007
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.39205.386609.80